Multiple Myeloma and Cervical Cancer
FGFR3 mutations that lead to multiple myeloma and cervical cancer are thought to over activate the fibroblast growth factor receptor 3 protein in certain cells. The mutated receptor directs the cells to grow and divide in the absence of signals from outside the cell. This uncontrolled division can lead to the overgrowth of cancer cells.
Cytogenetic location: 4p16.3
Molecular location on chromosome 4: base pairs 1,762,853 to 1,777,828
The FGFR3 gene is located on the short (p) arm of chromosome 4 at position 16.3.
More precisely, the FGFR3 gene is located from base pair 1,762,853 to base pair 1,777,828 on chromosome 4.
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