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Didronel Side Effects

Serious Side Effects Seen With Didronel

Some side effects with Didronel, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include, but are not limited to:
  • Throat pain, chest pain, or difficulty swallowing (which may be signs of ulcers of the esophagus)
  • Severe heartburn or heartburn that does not go away
  • Severe bone, muscle, or joint pain
  • Soft or weak bones (if the Didronel dosage is too high or is continued too long)
  • Jaw or tooth problems
  • Depression (see Didronel and Depression)
  • Hallucinations
  • Signs of an allergic reaction, including unexplained rash, hives, itching, wheezing, difficulty breathing, and unexplained swelling.

How to Minimize Didronel Side Effects on the Esophagus

In order to reduce the chance of developing serious esophageal side effects, you should follow the prescribed directions on how to take Didronel. For example:
  • Didronel should be taken on an empty stomach and with a full glass of water first thing in the morning.
  • Swallow the tablet whole. Do not suck or chew on the Didronel tablet.
  • Remain in an upright position (sitting up or standing) for 30 minutes after taking Didronel.
  • For at least two hours before and after taking Didronel, it is important to:


    • Wait to eat or drink. This includes mineral water, sparkling water, coffee, tea, milk, or juice. Plain water is okay.
    • Avoid taking any other oral medicine, including calcium supplements.


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