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Didronel Warnings and Precautions

Make sure to talk to your healthcare provider about Didronel warnings and precautions before taking the drug. Prior to beginning treatment, let your healthcare provider know if you have severe diarrhea, kidney disease, osteomalacia, or any allergies. It is important to know that Didronel may cause extreme muscle or bone pain, weak or soft bones, and diarrhea.

Didronel: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Didronel® (etidronate disodium) if you have:
  • Osteomalacia (soft bones due to a vitamin D deficiency)
  • Severe diarrhea
  • Kidney disease, including kidney failure (renal failure)
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding
  • Planning to have a dental procedure.
Make sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Didronel

Warnings and precautions to be aware of prior to taking Didronel include the following:
  • In rare cases, bisphosphonates (including Didronel) have caused a condition called osteonecrosis of the jaw. This is a serious, possibly disfiguring problem in which the bone of the jaw dies. Often, there are symptoms (such as pain, infection, or loosening of the teeth), but sometimes there are no symptoms until a person notices exposed bone. This problem is most common when bisphosphonates are given by IV (but is still possible when these medications are taken orally). It seems that people who have dental procedures (such as a tooth extraction) are also at higher risk. Be sure to take good care of your mouth and teeth by seeing your dentist frequently. Let your healthcare provider know right away if you think you may have osteonecrosis of the jaw.
  • It is important to get enough calcium and vitamin D (either through your diet or by supplementation). Calcium and vitamin D are necessary for rebuilding bone and preventing further bone loss. Didronel cannot work if you do not get enough calcium and vitamin D.
  • Didronel may not be recommended for people with severe kidney disease.
  • Bisphosphonates (including Didronel) can cause extreme muscle or bone pain. This usually goes away once the medication is stopped.
  • Didronel can cause weak or soft bones, which can lead to broken bones and other problems. This is most likely if the Didronel dosage is too high or if the drug is used continuously (it is meant to be used only for a specific length of time).
  • Didronel can cause diarrhea. If you have severe diarrhea (from any cause), you may need to stop taking Didronel for a while.
  • Didronel can potentially interact with a number of medications (see Didronel Drug Interactions).
  • Didronel is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy (see Didronel and Pregnancy).
  • It is not known whether Didronel passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Didronel and Breastfeeding).
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