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Jakafi Dosage

When used to treat myelofibrosis, the recommended dosage of Jakafi will depend on several factors, such as your platelet count, how you respond to the drug, and other medications you are taking. The starting dose is typically 15 mg or 20 mg taken twice daily. Your healthcare provider may adjust your dosage as necessary, up to a maximum of 25 mg twice daily.

An Introduction to Dosing With Jakafi

The dose of Jakafi™ (ruxolitinib) your healthcare provider recommends will vary, depending on the following factors:
 
  • Your platelet (a type of blood cell) count
  • How you respond to the medication
  • Other medical conditions you may have
  • Other medications you are taking.
 
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Recommended Jakafi Dosage

The recommended starting dosage of Jakafi for the treatment of myelofibrosis is 15 mg or 20 mg twice daily, depending on your platelet count. Your healthcare provider will get a platelet count, using a simple blood test, before you start treatment to determine your initial Jakafi dose. If your platelet count is too low, your healthcare provider may recommend waiting to start Jakafi until your platelet counts increase.
 
The recommended starting dose of Jakafi is 10 mg twice daily for people who:
 
  • Have moderate or severe kidney disease
  • Have liver disease
  • Are taking certain medications known as CYP 3A4 inhibitors (see Jakafi Drug Interactions for examples of CYP 3A4 inhibitor medications).
 
The usual starting dose of Jakafi for people on kidney dialysis is 15 mg or 20 mg, depending on platelet counts. Doses should be given on days of dialysis, after dialysis is completed.
 
Your dosage may be adjusted based on how you respond to treatment and your platelet counts. Your healthcare provider will get a platelet count every two to four weeks until you are on a stable Jakafi dose, and as needed for the remainder of treatment. If your platelet count becomes too low, you may need to take a lower Jakafi dosage or temporarily stop treatment until your platelet count recovers.
 
If you are not adequately responding to treatment after at least four weeks of taking Jakafi, your healthcare provider may slowly increase your dosage (usually by 5 mg twice daily). Doses should normally be increased no more often than every two weeks. The maximum recommended dosage is 25 mg twice daily. It is generally recommended that treatment be stopped if your spleen has not reduced in size or your symptoms (such as fatigue) have not improved after six months of treatment.
 
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Jakafi Medication Information

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