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Jakafi Uses

How Does It Work?

Jakafi works by blocking two enzymes in the body known as janus-associated kinase 1 (JAK1) and 2 (JAK2). These two enzymes help control the formation of blood cells. Myelofibrosis is associated with abnormal activity of JAK1 and JAK2, which causes blood cells to be made in organs such as the spleen. This, in turn, leads to enlargement of the spleen.
 
By inhibiting the action of the abnormal JAK1 and JAK2 enzymes, Jakafi can help reduce spleen size and subsequent symptoms of myelofibrosis.
 

Is It Safe for Children to Use Jakafi?

This medication is not approved for use in children, as it has not been adequately studied in this age group. Talk to your child's healthcare provider about the risks and benefits of using Jakafi in children.
 

Can Older Adults Use Jakafi?

In clinical studies, older adults responded no differently to Jakafi than younger age groups. However, some older adults may be more sensitive to the effects of this medication, and may need to be monitored more closely.
 

Off-Label Jakafi Uses

On occasion, healthcare providers may recommend medications for treating something other than the approved uses. This is called an "off-label" use. At this time, there are no well-accepted, off-label uses for Jakafi.
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Jakafi Medication Information

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