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Osteogenesis Imperfecta

Types of Osteogenesis Imperfecta

In 1979, Sillence and others devised a classification scheme that divides osteogenesis imperfecta into four types (two additional types have subsequently been added).
  • Type I OI
  • Type II OI
  • Type III OI
  • Type IV OI
  • Type V OI
  • Type VI OI.

Symptoms of Osteogenesis Imperfecta

Osteogenesis imperfecta symptoms vary significantly according to type, and it is difficult to predict what symptoms or complications a person will have.
The characteristic symptoms of the condition also vary greatly from person to person, even among people with the same type of osteogenesis imperfecta, and even within the same family. In addition, not all symptoms are evident in each case.
Common symptoms include:
  • Bones that fracture easily
  • Short stature
  • Skeletal deformities of limbs, chest, and skull
  • Scoliosis (curvature of the spine)
  • Hearing loss
  • Respiratory difficulties
  • Loose joints and ligaments
  • Discolored, brittle teeth
  • Blue sclera (blue color in the whites of the eyes)
  • Constipation
  • Weak muscles
  • Excessive sweating
  • Tendency to bruise easily
  • High-pitched voice.
Keep in mind that very few people with the condition exhibit all of these symptoms and that the severity of each symptom can vary tremendously between individuals.
(Click Osteogenesis Imperfecta Symptoms to learn about the symptoms of each OI type.)
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